Britschgi and co-investigators  described a case of a metastatic non-small cell lung cancer patient who had a com- plete response secondary to an abscopal effect of stereotactic body radiation therapy delivered in combination with anti- programmed cell death protein 1 (PD-1) immunotherapy with nivolumab. Following the progression with the nivolumab therapy, the patient received stereotactic body radiation thera- py to a dose of 18 Gy delivered in 6 fractions to two of the three lymph node metastatic lesions while continuing immu- notherapy. Ten weeks post-radiation therapy, a complete ra- diological and metabolic response was seen in not only the irradiated lymph node metastatic lesions but also in the non- irradiated lesion of the third lymph node revealing the abscopal effect of radiation therapy.
Cong et al.  reported an abscopal response in a patient with metastatic NSCLC. Following the diagnosis of NSCLC, after a failed first-line chemotherapy with cisplatin and pemetrexed, the patient received gefitinib therapy. In addition, the patient received the first dendritic cells and cytokine- induced killers (DC-CIK) immunotherapy. However, the pa- tient showed a marked tumor progression in the lung. The patient then received stereotactic ablative radiation therapy (SABRT) to a dose of 37.5 Gy in 5 daily fractions for the paramediastinal foci. A follow-up chest X-ray performed 10 months after completion of SABRT showed a complete regression of pulmonary lesions suggesting an abscopal re- sponse of radiation therapy.
Katayama and colleagues  reported the abscopal effects of radiation therapy in a patient with metastatic NSCLC. This patient underwent whole brain radiation therapy (WBRT) plus a boost of radiation therapy to a total dose of 45 Gy delivered in 15 fractions. The metastatic brain tumor presented with cerebral edema from the left temporal lobe to the occipital lobe rapidly progressed after the enucleation of their brain tumor. The patient also received palliative radiation (30 Gy in 10 fractions) for a third lumbar vertebral metastasis. The tumor in the left upper lobe of the lung and his mediastinal lymph nodes had regressed in size indicating the abscopal effects of radiation therapy. Furthermore, these authors con- cluded that the abscopal effect can occur after the irradiation of metastatic lesions without chemotherapeutic or immuno- therapeutic interventions.
effect of radiation therapy in a patient with neuroendocrine atypical carcinoid lung cancer. In this case, the patient underwent palliative radiation with 30 Gy delivered in 10 fractions targeted to a symptomatic calvarial metastasis. One month after radiation, she noted a rapid im- provement in her skin nodules suggesting the abscopal effects of radiation therapy. The patient had a durable complete re- sponse post-radiation even after 18 months had passed.
Komatsu and co-investigators  reported on a case of the abscopal response in a lung cancer patient who progressed on